Her2 Breast Cancer Project

Analysis workflow for MRC-IEU PhD mini-project on childhood BMI effect on breast cancer

Machine learning is widely used in bioinformatics and particularly in breast cancer diagnosis. In this project, certain classification methods such as K-nearest neighbors (K-NN) and Support Vector Machine (SVM) which is a supervised learning method to detect breast cancer are used.

BreakHist Dataset contains histopathological images of eight types of breast cancer, including four benign cancer and for malignant cancer. In this project, I have trained and fined tuned many of the existing CNN models to get over 80% accuracy in multi-class classification.

Breast Cancer Detection using ML

This project uses mammograms for breast cancer detection using deep learning techniques.

This project aims to predict people who will survive breast cancer using machine learning models with the help of clinical data and gene expression profiles of the patients.

This project utilizes a sophisticated deep learning model trained to classify breast ultrasound images into three categories: benign, malignant, or normal, thus determining the presence of breast cancer.

Breast cancer has the second highest mortality rate in women next to lung cancer. As per clinical statistics, 1 in every 8 women is diagnosed with breast cancer in their lifetime. However, periodic clinical check-ups and self-tests help in early detection and thereby significantly increase the chances of survival. Invasive detection techniques cause rupture of the tumor, accelerating the spread of cancer to adjoining areas. Hence, there arises the need for a more robust, fast, accurate, and efficient non-invasive cancer detection system. Early detection can give patients more treatment options. In order to detect signs of cancer, breast tissue from biopsies is stained to enhance the nuclei and cytoplasm for microscopic examination. Then, pathologists evaluate the extent of any abnormal structural variation to determine whether there are tumors. Architectural Distortion (AD) is a very subtle contraction of the breast tissue and may represent the earliest sign of cancer. Since it is very likely to be unnoticed by radiologists, several approaches have been proposed over the years but none using deep learning techniques. AI will become a transformational force in healthcare and soon, computer vision models will be able to get a higher accuracy when researchers have the access to more medical imaging datasets. The application of machine learning models for prediction and prognosis of disease development has become an irrevocable part of cancer studies aimed at improving the subsequent therapy and management of patients. The application of machine learning models for accurate prediction of survival time in breast cancer on the basis of clinical data is the main objective. We have developed a computer vision model to detect breast cancer in histopathological images. Two classes will be used in this project: Benign and Malignant

This is a deep learning project to classify breast cancer (Birads from 1 to 5) from mammography and CEDM Images.

Breast Cancer Prediction Project

A simple neural network built with TensorFlow/Keras to classify tumors as malignant or benign using the Breast Cancer Wisconsin dataset. Includes data preprocessing, model training, evaluation, and result visualization. This project demonstrates how deep learning can assist in medical diagnosis.

🩺 Advanced neural network for breast cancer classification using Wisconsin dataset. Analyzes cell nucleus characteristics from FNA samples to distinguish malignant/benign masses with 96.5% accuracy. Features comprehensive documentation, automated setup, testing framework, and deployment guides. Educational ML project with 15,000+ lines of docs.

Different approaches as (ANN,RandomForest,Bayes and KNeighbors) to solve and predict with the best accuracy malignous cancers

Repository for CUNY Capstone Project on Breast Cancer detection

DiagnoSys is a comprehensive web application that provides advanced detection and analysis for various health conditions. This project leverages state-of-the-art machine learning algorithms to detect and diagnose COVID-19, Alzheimer's disease, breast cancer, and pneumonia using X-ray and MRI datasets.

This project analyzes breast cancer data using Python, employing libraries for data manipulation, visualization, and machine learning. The main objectives are to explore the dataset, visualize insights, and implement classification algorithms to predict breast cancer diagnoses.

A deep learning project aimed at early detection of breast cancer by classifying tumors as benign or malignant based on features extracted from cell images. The project demonstrates data preprocessing, model training, and evaluation using various deep learning algorithms to achieve high accuracy in predictions.

MR project investigating the mediating role of mammographic density in the childhood body size and breast cancer relationship

Final project of digital image processing (Breast cancer classification) using Matlab

Breast Cancer Detection Using Machine Learning Project Code, PPT, Synopsis, Report and Video Explanation

This project includes multiple disease prediction models for diabetes, Parkinson's disease, heart disease, and breast cancer.

This personal project incorporates a machine learning model to detect breast cancer using a dataset by scikit-learn. By using Logistic Regression the model is trained to classify tumors to either a malignant (cancerous) class or a benign (non-cancerous) class, offering reliable predictions for simple binary medical classification tasks.

Content Past Usage: Attributes 2 through 10 have been used to represent instances. Each instance has one of 2 possible classes: benign or malignant. Wolberg,~W.~H., \& Mangasarian,~O.~L. (1990). Multisurface method of pattern separation for medical diagnosis applied to breast cytology. In {\it Proceedings of the National Academy of Sciences}, {\it 87}, 9193--9196. -- Size of data set: only 369 instances (at that point in time) -- Collected classification results: 1 trial only -- Two pairs of parallel hyperplanes were found to be consistent with 50% of the data -- Accuracy on remaining 50% of dataset: 93.5% -- Three pairs of parallel hyperplanes were found to be consistent with 67% of data -- Accuracy on remaining 33% of dataset: 95.9% Zhang,~J. (1992). Selecting typical instances in instance-based learning. In {\it Proceedings of the Ninth International Machine Learning Conference} (pp. 470--479). Aberdeen, Scotland: Morgan Kaufmann. -- Size of data set: only 369 instances (at that point in time) -- Applied 4 instance-based learning algorithms -- Collected classification results averaged over 10 trials -- Best accuracy result: -- 1-nearest neighbor: 93.7% -- trained on 200 instances, tested on the other 169 -- Also of interest: -- Using only typical instances: 92.2% (storing only 23.1 instances) -- trained on 200 instances, tested on the other 169 Relevant Information: Samples arrive periodically as Dr. Wolberg reports his clinical cases. The database therefore reflects this chronological grouping of the data. This grouping information appears immediately below, having been removed from the data itself: Group 1: 367 instances (January 1989) Group 2: 70 instances (October 1989) Group 3: 31 instances (February 1990) Group 4: 17 instances (April 1990) Group 5: 48 instances (August 1990) Group 6: 49 instances (Updated January 1991) Group 7: 31 instances (June 1991) Group 8: 86 instances (November 1991) Total: 699 points (as of the donated datbase on 15 July 1992) Note that the results summarized above in Past Usage refer to a dataset of size 369, while Group 1 has only 367 instances. This is because it originally contained 369 instances; 2 were removed. The following statements summarizes changes to the original Group 1's set of data: Group 1 : 367 points: 200B 167M (January 1989) Revised Jan 10, 1991: Replaced zero bare nuclei in 1080185 & 1187805 Revised Nov 22,1991: Removed 765878,4,5,9,7,10,10,10,3,8,1 no record : Removed 484201,2,7,8,8,4,3,10,3,4,1 zero epithelial : Changed 0 to 1 in field 6 of sample 1219406 : Changed 0 to 1 in field 8 of following sample: : 1182404,2,3,1,1,1,2,0,1,1,1 Number of Instances: 699 (as of 15 July 1992) Number of Attributes: 10 plus the class attribute Attribute Information: (class attribute has been moved to last column) Attribute Domain Sample code number id number Clump Thickness 1 - 10 Uniformity of Cell Size 1 - 10 Uniformity of Cell Shape 1 - 10 Marginal Adhesion 1 - 10 Single Epithelial Cell Size 1 - 10 Bare Nuclei 1 - 10 Bland Chromatin 1 - 10 Normal Nucleoli 1 - 10 Mitoses 1 - 10 Class: (2 for benign, 4 for malignant) Missing attribute values: 16 There are 16 instances in Groups 1 to 6 that contain a single missing (i.e., unavailable) attribute value, now denoted by "?". Class distribution: Benign: 458 (65.5%) Malignant: 241 (34.5%) Acknowledgements O. L. Mangasarian and W. H. Wolberg: "Cancer diagnosis via linear programming", SIAM News, Volume 23, Number 5, September 1990, pp 1 & 18. William H. Wolberg and O.L. Mangasarian: "Multisurface method of pattern separation for medical diagnosis applied to breast cytology", Proceedings of the National Academy of Sciences, U.S.A., Volume 87, December 1990, pp 9193-9196. O. L. Mangasarian, R. Setiono, and W.H. Wolberg: "Pattern recognition via linear programming: Theory and application to medical diagnosis", in: "Large-scale numerical optimization", Thomas F. Coleman and Yuying Li, editors, SIAM Publications, Philadelphia 1990, pp 22-30. K. P. Bennett & O. L. Mangasarian: "Robust linear programming discrimination of two linearly inseparable sets", Optimization Methods and Software 1, 1992, 23-34 (Gordon & Breach Science Publishers). Inspiration Rouse Tek Bio informatics Cytogenomics Project is an attempt to bring the human genome to the understanding of how cancers develop. All of our bodies are composed of cells. The human body has about 100 trillion cells within it. And usually those cells behave in a certain fashion. They observe certain rules, they divide when they’re told to divide, they’re quiescent when they’re told to remain dormant, they stay within a particular position within their tissue and they don’t move out of that. Occassionally however, a single cell, of those 100 trillion cells, behave in a different way. That cell keeps dividing when all its signals around it tell it to stop dividing. That cell ignores its counterparts around it and pushes them out of the way. That cell stops observing the rules of the tissue within which it is located and begins to move out of its normal position, invading into the tissues around it and sometimes entering the bloodstream and becoming a metastasis, depositing in another tissue of the body.. The reason the cell has gone rogue is because it has acquired within its genome, within its DNA, a number of abnormalities that cause it to behave as a cancer cell. All 100 trillion cells in the human body have got a copy of the human genome, they have 2 copies, 1 maternal, 1 paternal. Throughout Life all those copies of the genome in those 100 trillion cells, are acquiring abnormal changes or somatic mutations. These mutations are present in the cell and are not transmitted from parents to offspring. They are constrained to that individual cell. Those mutations occur in every cell of the body, normal and abnormal, for a number of different reasons. They occur because every time a cell divides possibly one letter of code out of 3 billion is replicated incorrectly. And that’s 1 source of somatic mutations. Another source is that our 100 trillion cells are being exposed to a number of different onslaughts like radiation, self generated chemicals from inhalation of things like tobacco smoke or even an unhealthy diet over time. Occasionally mechanisms in a particular cell make breakdown and the DNA of that cell begins to acquire somatic mutations rather more commonly than other cells. So in summary, every cell in the body acquires mutations throughout a lifetime, and as we get older we acquire more and more somatic mutations in which occasionally a particular type of gene is mutated where the protein that it makes is abnormal and drives the cell to behave in a rogue fashion that we call cancer.

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The project involves the development of ANN for predicting breast cancer using coimbra dataset

This project leverages the power of U-Net architecture implemented in PyTorch for breast cancer image segmentation.

This project is a part of research on Breast Cancer Diagnosis with Machine Learning algorithm using data-driven approaches. The final outcomes of the research were later published at an IEEE Conference and added to IEEE Xplore Digital Library.

Regarding the data, all 628 screening mammograms in this project have been classified as ab-normal by 2 radiologists and thus require a biopsy. Radiologists are cautious during screenings, the consequences of having a false negative push them to send women for biopsy if there is the slight-est doubt for them to have cancer. As explained, this results in a high number of false positive since the ‘cost’ is lower than having a false negative. The dataset used in this project comes from the OPTIMAM Medical Image Database, which collects NHS Breast Screening Programme (NHSB-SO) images in the UK. A deep learning approach is used to classify abnormal screenings as either malignant or benign cancer with a certain probability. Transfer Learning makes it possible to obtain high performances on small datasets. This project achieved a ROC of 80%, 86% sensitivity, and 77% NPV, which were reached with a pre-trained ResNet50v2, a state-of-the-art neural network optimized through fine-tuning hy-perparameters and data pre-processing.

Machine Learning Web App Built Using Flask Deployed on Heroku