An example of analogue design using open source IC design tools

One of the most important tasks in drug design is to predict, among a series of lead candidates, which ones will bind more strongly to the therapeutic target. In this direction, relative binding free energy methodologies have been developed, which rely on physics-based molecular simulations and rigorous statistical mechanics to calculate the differences in the free energy of binding between a parent candidate drug and analogues. For example, Free Energy Perturbation (FEP) calculations calculate the free energy difference between an initial (reference) and a final (target) molecule to an average of a function of their energy difference evaluated by sampling for the initial state. Automating free energy perturbation calculations is a step forward to delivering high throughput calculations for accurate predictions of relative binding affinities before a compound is synthesized, and consequently save enormous time and cost. NAMD is a free parallel molecular dynamics code, designed for high-performance simulations of large biomolecular systems. Although FEP calculations are possible with NAMD, no automated tool has been developed to streamline the process, making the calculations tedious and unfeasible for a large number of molecules. That gave us the motivation to provide an easily accessible web based preparation tool which can produce all the files needed to run a NAMD simulation.

This is another example of the Strategy Design pattern, coded in C#. The user can select which format they want to display the time (analogue or digital), and change their choice while the clock is running.

Understanding Small Signal vs Large Signal Models made easy! Complete tutorial with equations, step-by-step examples, and simple analogies. Covers Q-point analysis, MOSFET behaviour, and common source amplifier design. Perfect for ECE undergraduates studying analogue circuits.