Langchain-Chatchat（原Langchain-ChatGLM）基于 Langchain 与 ChatGLM, Qwen 与 Llama 等语言模型的 RAG 与 Agent 应用 | Langchain-Chatchat (formerly langchain-ChatGLM), local knowledge based LLM (like ChatGLM, Qwen and Llama) RAG and Agent app with langchain

A simple screen parsing tool towards pure vision based GUI agent

Run agents that work for you based on what you do. AI finally knows what you are doing

GUI for ChatGPT API and many LLMs. Supports agents, file-based QA, GPT finetuning and query with web search. All with a neat UI.

Ghostty-based macOS terminal with vertical tabs and notifications for AI coding agents

Trae Agent is an LLM-based agent for general purpose software engineering tasks.

Let AI agents browse the web. An autonomous toolkit for browser-based AI agents.

An Easy-to-use, Scalable and High-performance Agentic RL Framework based on Ray (PPO & DAPO & REINFORCE++ & TIS & vLLM & Ray & Async RL)

The paper list of the 86-page SCIS cover paper "The Rise and Potential of Large Language Model Based Agents: A Survey" by Zhiheng Xi et al.

A customisable 3D platform for agent-based AI research

🔍 An LLM-based Multi-agent Framework of Web Search Engine (like Perplexity.ai Pro and SearchGPT)

AppAgent: Multimodal Agents as Smartphone Users, an LLM-based multimodal agent framework designed to operate smartphone apps.

The official Lark/Feishu CLI tool, maintained by the larksuite team — built for humans and AI Agents. Covers core business domains including Messenger, Docs, Base, Sheets, Calendar, Mail, Tasks, Meetings, and more, with 200+ commands and 19 AI Agent Skills.

A complete web-based remote monitoring and management web site. Once setup you can install agents and perform remote desktop session to devices on the local network or over the Internet.

The agent-native LLM router for OpenClaw. 41+ models, <1ms routing, USDC payments on Base & Solana via x402.

ClawX is a desktop app that provides a graphical interface for OpenClaw AI agents. It turns CLI-based AI orchestration into a desktop experience without using the terminal. China website is https://clawx.com.cn.

🤖 AgentVerse 🪐 is designed to facilitate the deployment of multiple LLM-based agents in various applications, which primarily provides two frameworks: task-solving and simulation

结合知识库管理的 Agent Harness 平台。 An agent harness that integrates a LightRAG knowledge base and knowledge graphs. Build with LangChain v1 + Vue + FastAPI, support DeepAgents、MinerU PDF、Neo4j 、MCP.

👮 A PHP desktop/mobile user agent parser with support for Laravel, based on Mobiledetect

MaiSaka, an LLM-based intelligent agent, is a digital lifeform devoted to understanding you and interacting in the style of a real human. She does not pursue perfection, nor does she seek efficiency; instead, she values warmth, authenticity, and genuine connection.

⚡️AI Cloud OS: Open-source enterprise-level AI knowledge base and MCP (model-context-protocol)/A2A (agent-to-agent) management platform with admin UI, user management and Single-Sign-On⚡️, supports ChatGPT, Claude, Llama, Ollama, HuggingFace, etc., chat bot demo: https://ai.casibase.com, admin UI demo: https://ai-admin.casibase.com

Koog is a JVM (Java and Kotlin) framework for building predictable, fault-tolerant and enterprise-ready AI agents across all platforms – from backend services to Android and iOS, JVM, and even in-browser environments. Koog is based on our AI products expertise and provides proven solutions for complex LLM and AI problems

🤖 Build voice-based LLM agents. Modular + open source.

Mesa is an open-source Python library for agent-based modeling, ideal for simulating complex systems and exploring emergent behaviors.

Mirix is a multi-agent personal assistant designed to track on-screen activities and answer user questions intelligently. By capturing real-time visual data and consolidating it into structured memories, Mirix transforms raw inputs into a rich knowledge base that adapts to your digital experiences.

RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations. Despite their ubiquity, sequences are not always available for such RNAs. Standard methods facilitate such sequencing. In this note, we provide experimental sequence information for the RNA components of the initial Moderna (https://pubmed.ncbi.nlm.nih.gov/32756549/) and Pfizer/BioNTech (https://pubmed.ncbi.nlm.nih.gov/33301246/) COVID-19 vaccines, allowing a working assembly of the former and a confirmation of previously reported sequence information for the latter RNA. Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin. For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use. To obtain the small amounts of RNA needed for characterization, vaccine remnants were phenol-chloroform extracted using TRIzol Reagent (Invitrogen), with intactness assessed by Agilent 2100 Bioanalyzer before and after extraction. Although our analysis mainly focused on RNAs obtained as soon as possible following discard, we also analyzed samples which had been refrigerated (~4 ℃) for up to 42 days with and without the addition of EDTA. Interestingly a substantial fraction of the RNA remained intact in these preparations. We note that the formulation of the vaccines includes numerous key chemical components which are quite possibly unstable under these conditions-- so these data certainly do not suggest that the vaccine as a biological agent is stable. But it is of interest that chemical stability of RNA itself is not sufficient to preclude eventual development of vaccines with a much less involved cold-chain storage and transportation. For further analysis, the initial RNAs were fragmented by heating to 94℃, primed with a random hexamer-tailed adaptor, amplified through a template-switch protocol (Takara SMARTerer Stranded RNA-seq kit), and sequenced using a MiSeq instrument (Illumina) with paired end 78-per end sequencing. As a reference material in specific assays, we included RNA of known concentration and sequence (from bacteriophage MS2). From these data, we obtained partial information on strandedness and a set of segments that could be used for assembly. This was particularly useful for the Moderna vaccine, for which the original vaccine RNA sequence was not available at the time our study was carried out. Contigs encoding full-length spikes were assembled from the Moderna and Pfizer datasets. The Pfizer/BioNTech data [Figure 1] verified the reported sequence for that vaccine (https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/), while the Moderna sequence [Figure 2] could not be checked against a published reference. RNA preparations lacking dsRNA are desirable in generating vaccine formulations as these will minimize an otherwise dramatic biological (and nonspecific) response that vertebrates have to double stranded character in RNA (https://www.nature.com/articles/nrd.2017.243). In the sequence data that we analyzed, we found that the vast majority of reads were from the expected sense strand. In addition, the minority of antisense reads appeared different from sense reads in lacking the characteristic extensions expected from the template switching protocol. Examining only the reads with an evident template switch (as an indicator for strand-of-origin), we observed that both vaccines overwhelmingly yielded sense reads (>99.99%). Independent sequencing assays and other experimental measurements are ongoing and will be needed to determine whether this template-switched sense read fraction in the SmarterSeq protocol indeed represents the actual dsRNA content in the original material. This work provides an initial assessment of two RNAs that are now a part of the human ecosystem and that are likely to appear in numerous other high throughput RNA-seq studies in which a fraction of the individuals may have previously been vaccinated. ProtoAcknowledgements: Thanks to our colleagues for help and suggestions (Nimit Jain, Emily Greenwald, Lamia Wahba, William Wang, Amisha Kumar, Sameer Sundrani, David Lipman, Bijoyita Roy). Figure 1: Spike-encoding contig assembled from BioNTech/Pfizer BNT-162b2 vaccine. Although the full coding region is included, the nature of the methodology used for sequencing and assembly is such that the assembled contig could lack some sequence from the ends of the RNA. Within the assembled sequence, this hypothetical sequence shows a perfect match to the corresponding sequence from documents available online derived from manufacturer communications with the World Health Organization [as reported by https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/]. The 5’ end for the assembly matches the start site noted in these documents, while the read-based assembly lacks an interrupted polyA tail (A30(GCATATGACT)A70) that is expected to be present in the mRNA.

AI agent framework for plan-first development workflows with approval-based execution. Multi-language support (TypeScript, Python, Go, Rust) with automatic testing, code review, and validation built for OpenCode

MiniAGI is a simple general-purpose AI agent based on the OpenAI API.

A repo lists papers related to LLM based agent

A lightweight framework for building LLM-based agents