Claude Code is an agentic coding tool that lives in your terminal, understands your codebase, and helps you code faster by executing routine tasks, explaining complex code, and handling git workflows - all through natural language commands.

An open-source long-horizon SuperAgent harness that researches, codes, and creates. With the help of sandboxes, memories, tools, skill, subagents and message gateway, it handles different levels of tasks that could take minutes to hours.

FCC China open source codebase and curriculum. Learn to code and help nonprofits.

🦔 PostHog is an all-in-one developer platform for building successful products. We offer product analytics, web analytics, session replay, error tracking, feature flags, experimentation, surveys, data warehouse, a CDP, and an AI product assistant to help debug your code, ship features faster, and keep all your usage and customer data in one stack.

实现最简 vue3 模型( Help you learn more efficiently vue3 source code )

Use Claude Code, Cursor CLI or Codex on mobile and web with CloudCLI (aka Claude Code UI). CloudCLI is a free open source webui/GUI that helps you manage your Claude Code session and projects remotely

JSHint is a tool that helps to detect errors and potential problems in your JavaScript code

Checkstyle is a development tool to help programmers write Java code that adheres to a coding standard. By default it supports the Google Java Style Guide and Sun Code Conventions, but is highly configurable. It can be invoked with an ANT task and a command line program.

The C++ REST SDK is a Microsoft project for cloud-based client-server communication in native code using a modern asynchronous C++ API design. This project aims to help C++ developers connect to and interact with services.

Code that'll help you kickstart a personal website that showcases your work as a software developer.

Provides functionality that helps writing PHP code that has runtime-specific execution paths

🚦 A pretty diagnostics, references, telescope results, quickfix and location list to help you solve all the trouble your code is causing.

mini-spring is a simplified version of the Spring framework that helps you quickly familiarize yourself with Spring source code and master Spring's core principles. It extracts Spring's core logic with extremely simplified code while preserving Spring's core functionality.

A specialized Claude Code workspace for creating long-form, SEO-optimized blog content for any business. This system helps you research, write, analyze, and optimize content that ranks well and serves your target audience.

A tool to help migrate JavaScript code quickly and conveniently to TypeScript

Kodu is an autonomous coding agent that lives in your IDE. It is a VSCode extension that can help you build your dream project step by step by leveraging the latest technologies in automated coding agents

An open-source vibe coding platform that helps you build your own vibe-coding platform, built entirely on Cloudflare stack

Welcome to New Expensify: a complete re-imagination of financial collaboration, centered around chat. Help us build the next generation of Expensify by sharing feedback and contributing to the code.

PHP QR Code library that helps you create QR codes in a jiffy

A tool to help eliminate NullPointerExceptions (NPEs) in your Java code with low build-time overhead

Application that will help you learn React fundamentals. Install this application locally - there's tutorial, code snippets and exercises. The main objective of this project is to help you get off the ground with React!

Type less, code more: Cody is an AI code assistant that uses advanced search and codebase context to help you write and fix code.

A drop-in universal library helps you to manage the navigation bar styles and makes transition animations smooth between different navigation bar styles while pushing or popping a view controller for all orientations. And you don't need to write any line of code for it, it all happens automatically.

RNA vaccines have become a key tool in moving forward through the challenges raised both in the current pandemic and in numerous other public health and medical challenges. With the rollout of vaccines for COVID-19, these synthetic mRNAs have become broadly distributed RNA species in numerous human populations. Despite their ubiquity, sequences are not always available for such RNAs. Standard methods facilitate such sequencing. In this note, we provide experimental sequence information for the RNA components of the initial Moderna (https://pubmed.ncbi.nlm.nih.gov/32756549/) and Pfizer/BioNTech (https://pubmed.ncbi.nlm.nih.gov/33301246/) COVID-19 vaccines, allowing a working assembly of the former and a confirmation of previously reported sequence information for the latter RNA. Sharing of sequence information for broadly used therapeutics has the benefit of allowing any researchers or clinicians using sequencing approaches to rapidly identify such sequences as therapeutic-derived rather than host or infectious in origin. For this work, RNAs were obtained as discards from the small portions of vaccine doses that remained in vials after immunization; such portions would have been required to be otherwise discarded and were analyzed under FDA authorization for research use. To obtain the small amounts of RNA needed for characterization, vaccine remnants were phenol-chloroform extracted using TRIzol Reagent (Invitrogen), with intactness assessed by Agilent 2100 Bioanalyzer before and after extraction. Although our analysis mainly focused on RNAs obtained as soon as possible following discard, we also analyzed samples which had been refrigerated (~4 ℃) for up to 42 days with and without the addition of EDTA. Interestingly a substantial fraction of the RNA remained intact in these preparations. We note that the formulation of the vaccines includes numerous key chemical components which are quite possibly unstable under these conditions-- so these data certainly do not suggest that the vaccine as a biological agent is stable. But it is of interest that chemical stability of RNA itself is not sufficient to preclude eventual development of vaccines with a much less involved cold-chain storage and transportation. For further analysis, the initial RNAs were fragmented by heating to 94℃, primed with a random hexamer-tailed adaptor, amplified through a template-switch protocol (Takara SMARTerer Stranded RNA-seq kit), and sequenced using a MiSeq instrument (Illumina) with paired end 78-per end sequencing. As a reference material in specific assays, we included RNA of known concentration and sequence (from bacteriophage MS2). From these data, we obtained partial information on strandedness and a set of segments that could be used for assembly. This was particularly useful for the Moderna vaccine, for which the original vaccine RNA sequence was not available at the time our study was carried out. Contigs encoding full-length spikes were assembled from the Moderna and Pfizer datasets. The Pfizer/BioNTech data [Figure 1] verified the reported sequence for that vaccine (https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/), while the Moderna sequence [Figure 2] could not be checked against a published reference. RNA preparations lacking dsRNA are desirable in generating vaccine formulations as these will minimize an otherwise dramatic biological (and nonspecific) response that vertebrates have to double stranded character in RNA (https://www.nature.com/articles/nrd.2017.243). In the sequence data that we analyzed, we found that the vast majority of reads were from the expected sense strand. In addition, the minority of antisense reads appeared different from sense reads in lacking the characteristic extensions expected from the template switching protocol. Examining only the reads with an evident template switch (as an indicator for strand-of-origin), we observed that both vaccines overwhelmingly yielded sense reads (>99.99%). Independent sequencing assays and other experimental measurements are ongoing and will be needed to determine whether this template-switched sense read fraction in the SmarterSeq protocol indeed represents the actual dsRNA content in the original material. This work provides an initial assessment of two RNAs that are now a part of the human ecosystem and that are likely to appear in numerous other high throughput RNA-seq studies in which a fraction of the individuals may have previously been vaccinated. ProtoAcknowledgements: Thanks to our colleagues for help and suggestions (Nimit Jain, Emily Greenwald, Lamia Wahba, William Wang, Amisha Kumar, Sameer Sundrani, David Lipman, Bijoyita Roy). Figure 1: Spike-encoding contig assembled from BioNTech/Pfizer BNT-162b2 vaccine. Although the full coding region is included, the nature of the methodology used for sequencing and assembly is such that the assembled contig could lack some sequence from the ends of the RNA. Within the assembled sequence, this hypothetical sequence shows a perfect match to the corresponding sequence from documents available online derived from manufacturer communications with the World Health Organization [as reported by https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/]. The 5’ end for the assembly matches the start site noted in these documents, while the read-based assembly lacks an interrupted polyA tail (A30(GCATATGACT)A70) that is expected to be present in the mRNA.

Lazy Predict help build a lot of basic models without much code and helps understand which models works better without any parameter tuning

The Alexa Skills Kit SDK for Node.js helps you get a skill up and running quickly, letting you focus on skill logic instead of boilerplate code.

Flowistry is an IDE plugin for Rust that helps you focus on relevant code.

Mago is a toolchain for PHP that aims to provide a set of tools to help developers write better code.

The DirectX Tool Kit (aka DirectXTK) is a collection of helper classes for writing DirectX 11.x code in C++

API Dash is a beautiful AI-powered open-source cross-platform (Desktop & Mobile) API Client built using Flutter which can help you easily create & customize your HTTP & GraphQL API requests, visually inspect responses and generate API integration code. A lightweight alternative to postman/insomnia.